| Overview |
| bsm-52332R |
| RNF20 (3H7) Monoclonal Antibody |
| WB, FCM |
| Human, Mouse |
| Specifications |
| Unconjugated |
| Rabbit |
| Recombinant human RNF20 between 1 to 100 amino acids |
| Monoclonal |
| 3H7 |
| IgG |
| 1ug/ul |
| Purified by Protein A. |
| Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide. |
| Store at -20°C for 12 months. |
| Target |
| 56254 |
| Q5VTR2 |
| Nucleus |
| E3 ubiquitin-protein ligase BRE1A, RING finger protein 20, BRE1-A, hBRE1, BRE1A |
| Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. |
| Application Dilution |
| WB |
1:300-5000 |
| FCM |
1:20-100 |
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