| Overview |
| bsm-54023r-pbs-only-100ul |
| LXR alpha Recombinant Antibody, PBS Only Conjugated |
| WB, FCM, IF(ICC) |
| Human, Mouse, Rat |
| Specifications |
| PBS Only |
| Rabbit |
| C terminal Human LXR alpha |
| 60-110/447 |
| Monoclonal |
| 4A8 |
| IgG |
| Lot Dependent |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 10062 |
| Q13133 |
| Nucleus |
| Oxysterols receptor LXR-alpha; LXR alpha; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3; NR1H3; LXRA; RLD-1. |
| Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. |
| Application Dilution |
| WB |
1:500-2000 |
| FCM |
FCM1:50-100 |
| IF(ICC) |
IFICC1:50-200 |
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