ATG16L1 (1B6) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54215R |
| Product Name | ATG16L1 (1B6) Monoclonal Antibody |
| Applications |
WB
IF(ICC)
|
| Reactivity | Human, Mouse, Rat |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant protein within human ATG16L1 aa 1-150 |
| Clonality | Monoclonal |
| Clone # | 1B6 |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Target | |
| Gene ID | 55054 |
| Swiss Prot | Q676U5 |
| Subcellular location | Cytoplasm |
| Synonyms | Autophagy-related protein 16-1; APG16-like 1; ATG16L1; APG16L. |
| Background | Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production. Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Plays a role in regulating morphology and function of Paneth cell. |
| Application Dilution | |
| WB | 1:300-5000 |
| IF(ICC) | 1:50-200 |