Phospho-c-Myc(T58) Monoclonal Antibody
Applications
Reactivity
| Overview | |
| Catalog # | bsm-54563R |
| Product Name | Phospho-c-Myc(T58) Monoclonal Antibody |
| Applications |
WB
FCM
IF(ICC)
|
| Reactivity | Human |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | Recombinant protein |
| Modification Site | Thr58 |
| Clonality | Monoclonal |
| Clone # | 60D10 |
| Isotype | IgG |
| Concentration | Lot Dependent |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Store at -20°C for 12 months. |
| Target | |
| Gene ID | 4609 |
| Swiss Prot | P01106 |
| Subcellular location | Nucleus |
| Synonyms | Avian myelocytomatosis viral oncogene homolog antibody, bHLHe39 antibody, c Myc antibody, Class E basic helix-loop-helix protein 39 antibody, MRTL antibody, Myc antibody, Myc protein antibody, Myc proto oncogene protein antibody, Myc proto-oncogene protein antibody, myc related translation/localization regulatory factor antibody, MYC_HUMAN antibody, Myc2 antibody, MYCC antibody, Niard antibody, Nird antibody, Proto-oncogene c-Myc antibody, Transcription factor p64 antibody, v myc avian myelocytomatosis viral oncogene homolog antibody, v myc myelocytomatosis viral oncogene homolog antibody |
| Background | The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]. |
| Application Dilution | |
| WB | 1:300-5000 |
| FCM | 1:20-100 |
| IF(ICC) | 1:50-200 |