| Overview |
| bsm-58001R |
| FRATAXIN (2G1) Monoclonal Antibody |
| WB |
| Human |
| Specifications |
| Unconjugated |
| Rabbit |
| Full length recombinant human Frataxin protein |
| Monoclonal |
| 2G1 |
| IgG |
| Not Determined |
| Purified by Protein A. |
| 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 2395 |
| Q16595 |
| Frataxin, mitochondrial; FXN; Friedreich ataxia protein; FRDA; X25 |
| Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1. |
| Application Dilution |
| WB |
1:300-5000 |
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