| Overview |
| bsm-61905r-pbs-only-100ul |
| HIF1AN Recombinant Antibody, PBS Only Conjugated |
| WB, FCM, IHC-P, IHC-F, IF(IHC-P), IF(ICC) |
| Human |
| Specifications |
| PBS Only |
| Rabbit |
| KLH conjugated synthetic peptide derived from human HIF 1 alpha inhibitor |
| Recombinant |
| IgG |
| 1mg/ml |
| Purified by Protein A. |
| PBS (pH=7.4) |
| Store at 4°C for 12 months. |
| Target |
| 55662 |
| Q9NWT6 |
| Nucleus |
| FIH 1; FIH1; HIF1AN. |
| Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. |
| Application Dilution |
| WB |
1:500-2000 |
| FCM |
FCM1ug/test |
| IHC-P |
IHC-P1:200-500 |
| IHC-F |
IHC-F1:200-500 |
| IF(IHC-P) |
IFIHC-P1:200-500 |
| IF(ICC) |
IFICC1:100-200 |
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