| Overview |
| bsm-63166r-biotin-100ul |
| STAT1 Recombinant Antibody, Biotin Conjugated |
| WB, IHC-P, IHC-F, IP |
| Human, Mouse |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human STAT1 |
| Recombinant |
| IgG |
| 1mg/ml |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 6772 |
| P2224 |
| Cytoplasm, Nucleus |
| CANDF7; ISGF 3 ; Signal transducer and activator of transcription 1; 91kDa; Signal transducer and activator of transcription 1-alpha/beta; Stat1; STAT91; Transcription factor ISGF-3 components p91/p84. subunit; ITB1_HUMAN; very late activation protein, beta polypeptide; VLA BETA; VLA-4 subunit beta; VLA-BETA; VLAB; VLAbeta; Integrin β1 |
| The Stat1 transcription factor is activated in response to a large number of ligands (1) and is essential for responsiveness to IFN-α and IFN-γ (2,3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation, and DNA binding (4). Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa). In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors (5). In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-α and other cellular stresses (6). Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation. |
| Application Dilution |
| WB |
1:300-5000 |
| IHC-P |
1:200-400 |
| IHC-F |
1:100-500 |
| IP |
1-2ug |
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