| Overview |
| bsm-70094M |
| FTO (Fat mass and obesity related protein) Antibody |
| WB, ICC |
| Specific for endogenous levels of the ~58 kDa FTO protein. |
| Human, Mouse, Rat |
| Dog, Bovine, Sheep, Non-Human Primate |
| Specifications |
| Unconjugated |
| Mouse |
| Synthetic peptide corresponding to amino acid residues from the N-terminal region of rat FTO, conjugated to keyhole limpet hemocyanin (KLH). |
| Monoclonal |
| 5-2H10 |
| IgG2a |
| Lot Dependent |
| Purified by Protein G. |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 79068 |
| Q9C0B1 |
| AlkB homolog 9 antibody, ALKBH9 antibody, Alpha-ketoglutarate-dependent dioxygenase FTO antibody, AW743446 antibody, Fat mass and obesity-associated protein antibody, FATSO, MOUSE, HOMOLOG OF antibody, Fto antibody, FTO_HUMAN antibody, GDFD antibody, KIAA1752 antibody, mKIAA1752 antibody, Protein fatso antibody |
| The FTO gene is the most robust gene for common obesity characterized to date. FTO gene expression has been found to be significantly upregulated in the hypothalamus of rats after food deprivation and strongly negatively correlated with the expression of orexin peptide which is involved in the stimulation of food intake (Fredricksson R et al., 2008). Deletion analysis of FTO gene in mice showed that FTO is functionally involved in the control of both energy intake and energy expenditure (Fischer J et al., 2009). |
| Application Dilution |
| WB |
1:300-5000 |
| ICC |
1:100-500 |
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