| Overview |
| bsm-70271M |
| Synaptobrevin (VAMP) Antibody |
| WB, IHC |
| Specific for endogenous levels of the ~16 kDa synaptobrevin. The antibody has also been demonstrated to work in immunohistochemistry on formalin fixed, vibratome sections, but does not work on paraffin sections. |
| Human, Mouse, Rat, Bovine, Pig, Rabbit, Hamster |
| Specifications |
| Unconjugated |
| Mouse |
| Synaptic immunoprecipitate (crude) from human brain. |
| Monoclonal |
| SP10 |
| IgM |
| Lot Dependent |
| IgM Purified culture supernatant |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 6843 |
| P23763 |
| SYB antibody, SYB1 antibody, Synaptobrevin 1 antibody, VAMP antibody, VAMP1 antibody, Vesicle associated membrane protein 1 antibody |
| Synaptobrevin (aka VAMP) is an integral membrane protein of synaptic vesicles that plays a major role in the formation of larger SNARE complexes, along with SNAP-25 and syntaxin. Synaptobrevin has been shown to be essential for two fast synapse-specific membrane trafficking processes: fast exocytosis for neurotransmitter release and fast endocytosis that mediates rapid recycling of synaptic vesicles (Deak et al., 2004). Decreased levels of synaptobrevin in human hippocampus and cortex have been correlated with cognitive deficits in Alzheimer’s disease (Sze et al., 2000). |
| Application Dilution |
| WB |
1:300-5000 |
| IHC |
|
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