| Overview |
| bsm-70286M |
| Thyroid Hormone Receptor, α1/α2-Isotype Antibody |
| WB |
| Specific for endogenous levels of the ~50 kDa TR-α1 and the ~58 kDa TR-α2 proteins. |
| Human, Rat |
| Mouse, Dog, Non-Human Primate |
| Specifications |
| Unconjugated |
| Mouse |
| Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, α1/α2-isotype, conjugated to keyhole limpet hemocyanin (KLH). |
| Monoclonal |
| 1718 |
| IgG2a |
| Lot Dependent |
| Purified by Protein G. |
| 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol. |
| Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. |
| Target |
| 7067 |
| P10827 |
| c-erbA-1 antibody, C-erbA-alpha antibody, EAR-7 antibody, ERBA 1 antibody, ERBA antibody, ERBA related 7 antibody, Nuclear receptor subfamily 1 group A member 1 antibody, THA_HUMAN antibody, THRA antibody, Thra1 antibody, Thra2 antibody, Thyroid hormone receptor alpha 1 antibody, Thyroid hormone receptor alpha 2 antibody, Thyroid hormone receptor alpha antibody, TR alpha 1 antibody, TR alpha 2 antibody, Tra1 antibody, Triiodothyronine receptor antibody, V-erbA-related protein 7 antibody |
| Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). |
| Application Dilution |
| WB |
1:300-5000 |
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