Midkine Polyclonal Antibody

Overview
Catalog #	bs-1849r
Product Name	Midkine Polyclonal Antibody
Applications	IHC-P, IF(IHC-P)
Reactivity	Human, Rat
Predicted Reactivity	Mouse, Dog, Cow, Horse, Fruit Fly
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from mouse Midkine
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Store at -20C for 12 months.
Target
Gene ID	4192
Swiss Prot	P21741
Subcellular location	Secreted
Synonyms	MK; ARAP; NEGF2; Midkine; Amphiregulin-associated protein; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein; MDK; MK1
Background	Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
Application Dilution
IHC-P
IF(IHC-P)