PLCZ1 Antibody Blocking Peptide
| OVERVIEW | |
| CATALOG # | bs-5378P |
| bs-5378P |
PLCZ1 Antibody Blocking Peptide
|
| CONJUGATION | Unconjugated |
| SOURCE | This synthetic peptide is found within the protein C-X-C chemokine receptor type 3 isoform 2, and falls within the range of 10-40/415 amino acids. |
| PURIFICATION: | Purified by HPLC/MS. |
| STORAGE | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| TARGET | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1 |
| BACKGROUND |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5- trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
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