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Recombinant SARS-CoV-2 Nucleocapsid protein , N-His


Catalog # bs-41417P
Product Name Recombinant SARS-CoV-2 Nucleocapsid protein , N-His
Applications ELISA, SDS-PAGE
Conjugation Unconjugated
Source An E.coli expression system produces recombinant SARS-CoV-2 Nucleocapsid protein, and the target gene encoding Met1-Ala419 is expressed with His Tag
Storage Buffer Aqueous buffered solution containing 0.01M PBS(pH7.4) with 0.03% Proclin300.
Storage Condition The product should be stored at -70°C or -20°C.
Gene ID 43740575
Swiss Prot P0DTC9
Background Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.