Recombinant human FMN1 protein, His

Overview
Catalog #	bs-42131p-100ug
Product Name	Recombinant human FMN1 protein, His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human FMN1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-354/1419
Storage Buffer	20mM Tris (pH8.0) with 2M Urea.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	342184
Swiss Prot	Q68DA7
Background	The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. In mice, the limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of proteins known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing Actin filament assembly. Formins co-localize with the actin cytoskeleton and can translocate into the cell cytosol and into the nucleus in an HGF-dependent manner. Vertebrate nuclear formins can control polarizing activity in limb buds through establishment of a Sonic hedgehog/FGF-4 feedback loop. Deficiency mutations at the mammalian ld locus lead to profound developmental defects in limb and kidney formation. The human Formin 1 and 2 genes map to chromosome 15q13.3 and 1q43, respectively.