Recombinant human JAK1 protein, His

Overview
Catalog #	bs-42216p-100ug
Product Name	Recombinant human JAK1 protein, His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human JAK1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-331/1154
Storage Buffer	20mM Tris-Hcl (pH=7.4) with 8M Urea.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	3716
Swiss Prot	P23458
Background	Janus kinase 1 (JAK1) is a member of a new class of non-receptor protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon recpeptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.