Recombinant human DMP1 protein
Applications
Reactivity
| Overview | |
| Catalog # | bs-42333P-100ug |
| Product Name | Recombinant human DMP1 protein |
| Applications | Others |
| Reactivity | Others |
| Specifications | |
| Conjugation | Unconjugated |
| Source | Recombinant human DMP1 protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 18-131/513 |
| Storage Buffer | 0.01M TBS(pH7.4) |
| Storage Condition | The product should be stored at -70°C or -20°C. |
| Target | |
| Gene ID | 1758 |
| Swiss Prot | Q13316 |
| Background | DMP-1 is a member of the small integrin ligand N-linked glycoprotein family. It is important for the mineralization of bone and dentin. DMP-1 is expressed in bone, tooth and hypertrophic cartilage. It is synthesized by preosteoblasts and contains a large number of acidic domains. DMP-1 localizes to the nucleus of undifferentiated osteoblasts where it functions as a transcriptional regulator for osteoblast-specific gene activation and induces osteoblast differentiation. During osteoblast maturation, DMP-1 undergoes a conformational change and becomes phosphorylated by casein kinase II in response to an influx of calcium ions to the nucleus. DMP-1 is then exported to the extracellular matrix (ECM) where it regulates the nucleation of hydroxyapatite and the formation of calcified tissue. DMP-1 is proteolytically processed into N- and C-terminal fragments in the ECM of bone and dentin. The protein has also been identified in bone as a high molecular weight proteoglycan comprised of the N-terminal DMP-1 fragment and chondroitin sulfate.The loss of DMP-1 can result in hypomineralized bone. |
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