Recombinant human MTOR protein, N-His

Overview
Catalog #	bs-42341P-100ug
Product Name	Recombinant human MTOR protein, N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human MTOR protein is expressed in E.coli with N-His. It contains the amino acid sequence of 1-300/2549
Storage Buffer	20mM Tris-HCl (pH8.0) with 2M Urea.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	2475
Swiss Prot	P42345
Background	mTOR is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. In rat, it is a 289-kDa protein (symbolized RAFT1) with significant homology to the Saccharomyces cerevisiae protein TOR1 and has been shown to associate with the immunophilin FKBP12 in a rapamycin dependent fashion. The FKBP12-rapamycin complex is known to inhibit progression through the G1 cell cycle stage by interfering with mitogenic signaling pathways involved in G1 progression in several cell types, as well as in yeast. The binding of FRAP to FKBP12-rapamycin correlated with the ability of these ligands to inhibit cell cycle progression.