Recombinant human IKBKB protein

Overview
Catalog #	bs-42351P-100ug
Product Name	Recombinant human IKBKB protein
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human IKBKB protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 1-256/756
Storage Buffer	20mM Tris-HCl (pH8.0) with 2M Urea.
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	3551
Swiss Prot	O14920
Background	IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.