Recombinant human IGF1R protein, N-His

Overview
Catalog #	bs-42375P-100ug
Product Name	Recombinant human IGF1R protein, N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human IGF1R protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 741-932/1367
Storage Buffer	20mM Tris-Hcl (pH=8.0) with 2M Urea
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	3480
Swiss Prot	P08069
Background	This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.