Recombinant mouse MADCAM1 protein

Overview
Catalog #	bs-42393P-100ug
Product Name	Recombinant mouse MADCAM1 protein
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant mouse MADCAM1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 22-364/405
Storage Buffer	20mM Tris-Hcl (pH=8.0) with 8M Urea
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	17123
Swiss Prot	Q61826
Background	The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin Alpha 4/Beta 7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis.