| Overview |
| bs-42393P-100ug |
| Recombinant mouse MADCAM1 protein |
| Others |
| Others |
| Specifications |
| Unconjugated |
| Recombinant mouse MADCAM1 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 22-364/405 |
| 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| The product should be stored at -70°C or -20°C. |
| Target |
| 17123 |
| Q61826 |
| The recirculation of lymphocytes through different organs is thought to be regulated by adhesion molecules recognizing tissue-specific vascular addressins on the endothelium. The mucosal vascular addressin, MadCAM-1 (mucosal addressin cell adhesion molecule 1), is an immunoglobulin superfamily adhesion molecule for lymphocytes that is expressed by mucosal venules and helps direct lymphocyte traffic into Peyer’s patches and the intestinal lamina propria. MadCAM-1 acts as an endothelial cell ligand for leukocyte homing receptors L-Selectin and Integrin Alpha 4/Beta 7. MadCAM-1 is strongly expressed on inflamed portal vein/sinusoidal endothelium in autoimmune-mediated liver disease and plays a major contributory role in the progression of chronic experimental autoimmune encephalomyelitis. |
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