Recombinant mouse CLEC12A protein,N-His

Overview
Catalog #	bs-42413P-100ug
Product Name	Recombinant mouse CLEC12A protein,N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant mouse CLEC12A protein is expressed in E.coli with N-His. It contains the amino acid sequence of 69-267/267
Storage Buffer	20mM Tris-Hcl (pH=8.0) with 8M Urea
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	160364
Swiss Prot	Q5QGZ9
Background	The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-12A (C-type lectin domain family 12, member A), also known as CLL1, MICL, CLL-1 or DCAL-2, is a 275 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Existing as multiple alternatively spliced isoforms that are expressed in neutrophils, eosinophils, monocytes and dendritic cells, CLEC-12A functions as a cell surface receptor that acts as a negative regulator of granulocyte and monocyte function and, via this activity, modulates signaling cascades. CLEC-12A is highly subject to post-translational glycosylation at its N-terminus and may also exist as a homodimer.