| Overview |
| bs-42424P-100ug |
| Recombinant mouse SKI protein, GST&His |
| Others |
| Others |
| Specifications |
| Unconjugated |
| Recombinant mouse SKI protein is expressed in E.coli with GST&His. It contains the amino acid sequence of 248-453/728 |
| 20mM Tris-Hcl (pH=8.0) with 8M Urea |
| The product should be stored at -70°C or -20°C. |
| Target |
| 20481 |
| Q60698 |
| SKI is a nuclear protein that forms homodimers and heterodimers and binds to DNA to function as transcriptional activators and repressors. The SKI oncoprotein dramatically affects cell growth, differentiation, and/or survival. SKI was shown to act in distinct signaling pathways including those involving nuclear receptors, transforming growth factor beta, and tumor suppressors. SKI inhibits transforming growth factor-beta (TGF-beta) signaling through interaction with Smad proteins. SKI represses Smad-mediated transcriptional activation, probably through its action as a transcriptional co-repressor. SKI also inhibits TGF-beta-induced downregulation of genes such as c-myc. |
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