Recombinant human NOX2 protein, N-His

Overview
Catalog #	bs-42484p-100ug
Product Name	Recombinant human NOX2 protein, N-His
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant human NOX2 protein in E.coli with N-His. It contains the amino acid sequence of 283-570/570
Storage Buffer	20mM Tris-HCL (pH=9.0) with 8M Urea
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	1536
Swiss Prot	P04839
Background	NOX2/gp91phox is a critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. It also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc. Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD). X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections.