Recombinant mouse CD3E protein, C-mFc (HEK293)

Overview
Catalog #	bs-43509P-100ug
Product Name	Recombinant mouse CD3E protein, C-mFc (HEK293)
Applications	Others
Reactivity	Others
Specifications
Conjugation	Unconjugated
Source	Recombinant mouse CD3E protein is expressed in HEK293 cell with C-mFc . It contains the amino acid sequence of 23-108/189
Storage Buffer	0.01M TBS(pH7.4)
Storage Condition	The product should be stored at -70°C or -20°C.
Target
Gene ID	12501
Swiss Prot	P22646
Background	CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.