| Overview |
| bsm-52256r-rbitc-100ul |
| MLKL Recombinant Antibody, RBITC Conjugated |
| WB |
| Human |
| Specifications |
| RBITC |
| Rabbit |
| Human MLKL between 350 to C-terminus |
| 350-471/471 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 197259 |
| Q8NB16 |
| Cell membrane |
| Mixed lineage kinase domain-like protein, hMLKL; MLKL |
| Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610). |
| Application Dilution |
| WB |
1:300-5000 |
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