| Overview |
| bsm-54104r-biotin-100ul |
| phospho-MLKL (Ser345) Recombinant Antibody, Biotin Conjugated |
| WB, IP |
| Mouse |
| Specifications |
| Biotin |
| Rabbit |
| Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL |
| Ser345 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 74568 |
| Q9D2Y4 |
| Phospho-MLKL (S345); pMLKL Ser345; Mixed lineage kinase domain-like protein, Mlkl |
| Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| Application Dilution |
| WB |
1:300-5000 |
| IP |
1-2ug |
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