TMEM173 (1B8) Monoclonal Antibody

$Lane 1: U937 Cells; Lane 2: 293 Cells; Probed with TMEM173 (1B8) Monoclonal Antibody (bsm-54122R) at 1:1000 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.$

Lane 1: U937 Cells; Lane 2: 293 Cells; Probed with TMEM173 (1B8) Monoclonal Antibody (bsm-54122R) at 1:1000 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.

Flow cytometric analysis of THP-1 cells with TMEM173 (1B8) Monoclonal Antibody (bsm-54122R) at 1:100 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).

Applications

Reactivity

Human

Overview
Catalog #	bsm-54122R
Product Name	TMEM173 (1B8) Monoclonal Antibody
Applications	WB, FCM
Reactivity	Human
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Recombinant protein within human TMEM173 aa 200 to the C-terminus
Clonality	Monoclonal
Clone #	#REF!
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Store at 4C for up to 2 weeks. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Target
Gene ID	340061
Swiss Prot	Q86WV6
Synonyms	Stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; Mediator of IRF3 activation; Transmembrane protein 173; hSTING; ERIS; hMITA; TMEM173; ERIS; MITA; STING.
Background	Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Application Dilution
WB	1:300-5000
FCM	1:20-100