PSD93/DLG2 Recombinant Antibody

Flow cytometric analysis of SH-SY5Y cells with DLG2 (6D1) Monoclonal Antibody (bsm-54145R) at 1:100 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).

$Lane 1: Hela Cells; Lane 2: Mouse Thymus; Lane 3: SH-SY5Y Cells; Probed with DLG2 (6D1) Monoclonal Antibody (bsm-54145R) at 1:1000 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.$

Lane 1: Hela Cells; Lane 2: Mouse Thymus; Lane 3: SH-SY5Y Cells; Probed with DLG2 (6D1) Monoclonal Antibody (bsm-54145R) at 1:1000 overnight at 4\u00b0C followed by a conjugated secondary antibody for 60 minutes at 37\u00b0C.

Applications

WB
FCM
IHC-P

Reactivity

Human

Predicted Reactivity

Mouse
Rat

Overview
Catalog #	bsm-54145r
Product Name	PSD93/DLG2 Recombinant Antibody
Applications	WB, FCM, IHC-P
Reactivity	Human
Predicted Reactivity	Mouse, Rat
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Recombinant protein within human PSD93 aa 600-870
Clonality	Recombinant
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol
Storage Condition	Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	1740
Swiss Prot	Q15700
Synonyms	Disks large homolog 2; Channel-associated protein of synapse-110; Postsynaptic density protein PSD-93; Chapsyn-110; DLG2; discs large MAGUK scaffold protein 2; PSD93; PPP1R58;
Background	This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. DLG2 is required for the perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in the regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.
Application Dilution
WB	1:300-5000
FCM	1:20-100
IHC-P	1:200-400