| Overview |
| bsm-61410r-biotin-100ul |
| NUMB Recombinant Antibody, Biotin Conjugated |
| WB |
| Human, Mouse, Rat |
| Specifications |
| Biotin |
| Rabbit |
| KLH conjugated synthetic peptide derived from human NUMB |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C for 12 months. |
| Target |
| 8650 |
| P49757 |
| Cell membrane |
| c14_5527; h Numb; Numb; Numb homolog; S171. |
| Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling. |
| Application Dilution |
| WB |
1:300-5000 |
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