| Overview |
| bsm-61581r-bf350-100ul |
| PHD2 Recombinant Antibody, AbBy Fluor-350 Conjugated |
| WB |
| Human |
| Specifications |
| AbBy Fluor-350 |
| Rabbit |
| KLH conjugated synthetic peptide derived from human PHD2 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 54583 |
| Q9GZT9 |
| Cytoplasm, Nucleus |
| EGLN1; C1orf12; ECYT3; HIFPH2; HPH2; PHD2; SM-20; SM20; ZMYND6. |
| Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Application Dilution |
| WB |
1:300-5000 |
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