| Overview |
| bsm-62587r-rbitc-100ul |
| GRK6 Recombinant Antibody, RBITC Conjugated |
| WB |
| Human, Mouse |
| Specifications |
| RBITC |
| Rabbit |
| KLH conjugated synthetic peptide derived from human GRK6 |
| Recombinant |
| IgG |
| Lot dependent |
| Purified by Protein A. |
| Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
| Target |
| 2870 |
| P43250 |
| Cell membrane |
| G protein coupled receptor kinase 6; G protein coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; Gprk6; Grk6. |
| Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis.Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). |
| Application Dilution |
| WB |
1:300-5000 |
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