UCF-101

Overview
Catalog #	bs-82315c-5mg
Product Name	UCF-101
Specifications
Storage Buffer	Orange solid
Storage Condition	-20°C
Target
Product Information	UCF-101 is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM).1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3 Cell permeable.
Description	CAS Number: 313649-08-0 Chemical Name: Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione Molecular weight: 495.51 Formula: C27H17N3O5S Solubility: DMSO (30 mg/ml with warming) DMF (25 mg/ml) Physical Properties: Orange solid Purity: 98% by TLC