Pirfenidone

Overview
Catalog #	bs-82463c-5mg
Product Name	Pirfenidone
Specifications
Storage Buffer	Off-white solid
Storage Condition	RT
Target
Product Information	Antifibrotic agent. Prevents lung fibrosis in bleomycin-induced animal models.1 Down-regulates bleomycin-induced overexpression of lung procollagen I and III genes.2 Up-regulates RGS2 (Regulator of G-protein Signaling 2) which represents a new mechanism of pirfenidone action.3 Inhibits fibroblast proliferation.4 Suppresses TNFα production at the translational level.5 Scavenges hydroxyl radicals and inhibits lipid peroxidation in a dose-dependent manner.6 Recently approved therapeutic agent for idiopathic pulmonary fibrosis.7 Orally active.
Description	CAS Number: 53179-13-8 Chemical Name: 5-Methyl-1-phenyl-2(1H)-pyridinone Molecular weight: 185.23 Formula: C12H11NO Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)