Leflunomide

Overview
Catalog #	bs-82474c-50mg
Product Name	Leflunomide
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	A pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2. Although the molecule directly responsible for DHODH is actually A77 1726, a metabolite of Leflunomide. Rescues mice from acetaminophen-induced liver injury3.
Description	CAS Number: 75706-12-6 Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide Molecular weight: 270.21 Formula: C12H9F3N2O2 Solubility: DMSO (30 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (conforms)