CUDC-101

Overview
Catalog #	bs-82507c-5mg
Product Name	CUDC-101
Specifications
Storage Buffer	White or off-white solid
Storage Condition	-20°C
Target
Product Information	A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2, IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.1,2
Description	CAS Number: 1012054-59-9 Chemical Name: 7-((4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide Molecular weight: 434.49 Formula: C24H26N4O4 Solubility: DMSO (25 mg/ml) Physical Properties: White or off-white solid Purity: 99% by HPLC NMR (Conforms)