Riluzole

Overview
Catalog #	bs-82586c-20-mg
Product Name	Riluzole
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Riluzole is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS).1 Riluzole inhibits glutamate release via inactivation of voltage-dependent ion channels, effects expression and signal transduction of glutamate receptors, and facilitates glutamate uptake.2,3,4 It has also been investigated as a treatment for depression and anxiety.5 Riluzole induced apoptosis in mGluR1-expressing melanoma cells6, inhibited cell proliferation in a U87MG glioblastoma model via blockage of glutamate release7, and inhibited the growth of brain tumor stem-like cells via downregulation of GLUT3.
Description	CAS Number: 1744-22-5 Chemical Name: 2-Amino-6-(trifluoromethoxy)benzothiazole Molecular weight: 234.20 Formula: C8H5F3N2OS Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)