Kifunensine

Overview
Catalog #	bs-82600c-1mg
Product Name	Kifunensine
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Historically isolated from Kitasatosporia kifunensee.1 Inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum α-mannosidase I activity rescues the human α-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair α-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4
Description	CAS Number: 109944-15-2 Chemical Name: (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione Molecular weight: 232.19 Formula: C8H12N2O6 Solubility: DMSO (35 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (Conforms)