Embelin

Overview
Catalog #	bs-82619c-10mg
Product Name	Embelin
Specifications
Storage Buffer	Dark orange solid
Storage Condition	-20°C
Target
Product Information	Inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 μM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells3. Possesses anti-inflammatory and analgesic activity in vivo4. Cell-permeable.
Description	CAS Number: 550-24-3 Chemical Name: 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione Molecular weight: 294.39 Formula: C17H26O4 Solubility: DMSO (30 mg/ml) Ethanol (3 mg/ml) Physical Properties: Dark orange solid Purity: 98% by HPLC, NMR (Conforms)