EED-226

Overview
Catalog #	bs-82763c-5mg
Product Name	EED-226
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	EED-226 is a potent (IC50 = 23.4 nM) and selective allosteric inhibitor of the EED subunit of the methyltransferase polycomb repressive complex 2 (PRC2).1,2 It caused drastic proliferation inhibition in lymphoma cells with EZH2 mutations and caused shrinkage and slower tumor growth in mice using a subcutaneous xenograft model of Karpas422.
Description	CAS Number: 2083627-02-3 Chemical Name: N-(Furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolol[4,3-c)pyrimidine-5-amine Molecular weight: 369.40 Formula: C17H15N5O3S Solubility: DMSO (25 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC NMR (Conforms)