PITSTOP2

Overview
Catalog #	bs-82818c-5mg
Product Name	PITSTOP2
Specifications
Storage Buffer	Pink solid
Storage Condition	-20°C
Target
Product Information	PITSTOP2 inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition.1 It was able to cause a collapse of the nucleocytoplasmic permeability barrier and a reduction of Importin-ß binding.2 PITSTOP2 reduced viability in HeLa cells by trapping dividing cells in metaphase through loss of mitotic spindle integrity.3
Description	CAS Number: 1332879-52-3 Chemical Name: N-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide Molecular weight: 473.36 Formula: C20H13BrN2O3S2 Solubility: DMSO (>30 mg/ml) Physical Properties: Pink solid Purity: >98% by TLC NMR (Conforms)