20(S)-Hydroxycholesterol
| Overview | |
| Catalog # | bs-82906c-1mg |
| Product Name | 20(S)-Hydroxycholesterol |
| Specifications | |
| Storage Buffer | White solid |
| Storage Condition | -20°C |
| Target | |
| Product Information | 20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5 |
| Description | CAS Number: 516-72-3 Chemical Name: 5-Cholesten-3β, 20α-diol Molecular weight: 402.66 Formula: C27H46O2 Solubility: DMSO or Ethanol Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms) |
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