MF-438

Overview
Catalog #	bs-82920c-5mg
Product Name	MF-438
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	MF-438 is a potent inhibitor of stearoyl-CoA desaturase 1 (SCD1) - IC50 = 2.3 nM.1 MF-438 was potent in an in vivo mouse liver PD assay (ED50 between 1 and mg/kg).1 Cancer initiating cells (CSC-like) were shown to much more sensitive to MF-438 inhibition of SCD1 than progenitor and terminally differentiated cancer cells in a lung cancer model.2 MF-438 showed good oral bioavailability and metabolic stability making it an excellent tool for studying the effects of SCD1 in various disease models.
Description	CAS Number: 921605-87-0 Chemical Name: 2-Methyl-5-(6-(4-(2-trifluoromethyl)phenoxy)piperidin-3-yl)-1,3,4-thiadiazole Molecular weight: 421.44 Formula: C19H18F3N5OS Solubility: Ethanol (2 mg/ml), DMSO (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by HPLC, NMR (Confirms)