NH125

Overview
Catalog #	bs-83045c-5mg
Product Name	NH125
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	NH125 was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase.1 It was also found to be a potent inhibitor of eukaryotic elongation factor 2 (eEF-2) kinase (IC50 = 60 nM) with efficacy against a broad spectrum of human cancer cell lines.2 Other studies have linked the anticancer effects of NH125 to induction of eEF2 phosphorylation.3,4 NH125 has also been shown to engage the EIF2a-ATF4-CHOP axis resulting in induction of DR5 expression.5 Treatment of glioma stem cells with NH125 resulted in a sustained decrease in tumor volume via activation of integrated stress response (ISR) and GADD45 pathways.5
Description	CAS Number: 278603-08-0 Chemical Name: 1-Hexadecyl-2-methyl-3-(phenylmethyl)-1H-imidazlium iodide Molecular weight: 524.56 Formula: C27H45IN2 Solubility: DMSO (>25 mg/ml) Ethanol (>25 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC NMR (Conforms)