SR-717

Overview
Catalog #	bs-83048c-10mg
Product Name	SR-717
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM). It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMC’s.
Description	CAS Number: 2375421-09-1 Chemical Name: Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate Molecular weight: 381.27 Formula: C15H8F2N5O3·Li Solubility: DMSO (>25 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)