HET0016

Overview
Catalog #	bs-83104c-5mg
Product Name	HET0016
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	HET0016 (339068-25-6) inhibits 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis via omega oxidation of arachidonic acid mediated by CYP4A and 4F (IC50=8.9 nM in human renal microsomes).1 It displays neuroprotective effects in a rat model of traumatic brain injury via inhibition of neuronal pyroptosis.2 HET0016 attenuates cerebral ischemia-reperfusion injury3 as well as oxidative injury and peripheral nerve damage in type-2 diabetic mice4. It alleviates myocardial oxidative stress5 and restores endothelial function suggesting therapeutic potential in obesity-associated vascular disease6.
Description	CAS Number: 339068-25-6 Chemical Name: N-Hydroxy-N’-(4-butyl-2-methylphenyl)formamidine Molecular weight: 206.29 Formula: C12H18N2O Solubility: DMSO (20 mg/ml) Physical Properties: Off-white solid Purity: >98% by HPLC NMR (Conforms)