PSB-1584

Overview
Catalog #	bs-83111c-5mg
Product Name	PSB-1584
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	GPR84 is an orphan G protein-coupled receptor that is activated by medium-chain fatty acids and hydroxyfatty acids although these may not be its endogenous agonist.1 It is highly expressed on immune cells and expression levels rise after exposure to inflammatory stimuli.2 Potent synthetic agonists enhance proinflammatory signaling and macrophage effector functions.1 PSB-1584 is a potent synthetic exogenous agonist at GPR84, EC50=5 nM which is selective against other free fatty acid receptors and is metabolically stable when incubated with human liver microsomes.3 An important new tool for studying the physiology of GPR84.4
Description	CAS Number: 72255-76-6 Chemical Name: 6-hexylamino-2,4(1H,3H)-pyrimidinedione Molecular weight: 211.26 Formula: C10H17N3O2 Solubility: DMSO (35 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC, NMR (Conforms)