| Overview |
| bs-70101r |
| GABAA Receptor _6 Antibody |
| WB |
| Specific for endogenous levels of the ~57 kDa _6-subunit of the GABAA receptor. |
| Mouse, Rat |
| Specifications |
| Unconjugated |
| Rabbit |
| Synthetic peptide corresponding to amino acid residues specific to the _6 subunit of rat GABAA receptor, conjugated to keyhole limpet hemocyanin (KLH). |
| Polyclonal |
| IgG |
| Lot Dependent |
| Neat Pooled whole antiserum |
| Neat whole antiserum |
| Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20 C or -80 C, while keeping a working aliquot stored at 4 C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year. |
| Target |
| 29708 |
| P30191 |
| GABA A antibody, GABA A Receptor alph_6 polypeptide antibody, GABA A receptor alph_6 antibody, GABA A receptor subunit alph_6 antibody, GABA subunit A receptor alph_6 antibody, GABA(A) receptor subunit alpha-6 antibody, GABR_6 antibody, GABRA6 antibody, Gamma aminobutyric acid A receptor alph_6 antibody, Gamma aminobutyric acid GABA A receptor alph_6 antibody, Gamma aminobutyric acid receptor subunit alph_6 antibody, Gamma-aminobutyric acid receptor subunit alpha-6 antibody, GBRA6_HUMAN antibody, MGC116903 antibody, MGC116904 antibody |
| Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl_ channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six _s, four _s and four _s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for _- and _-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a _-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different _-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pltl et al., 2003). Lastly, phosphorylation of _-subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al., 2003). |
| Application Dilution |
| WB |
1:300-5000 |
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