Frizzled 9 Polyclonal Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-11842R |
| Product Name | Frizzled 9 Polyclonal Antibody |
| Applications |
WB
ELISA
IF(ICC)
|
| Specificity | This antibody may have slight cross reactivity with Frizzled 10. |
| Reactivity | Human |
| Predicted Reactivity | Mouse, Rat, Dog |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human Frizzled 9/CD349 |
| Immunogen Range | 185-270/591 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 8326 |
| Swiss Prot | O00144 |
| Subcellular location | Cell membrane |
| Synonyms | FZD3; CD349; Frizzled-9; Fz-9; hFz9; FzE6; FZD9 |
| Background | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| Application Dilution | |
| WB | 1:500-2000 |
| ELISA | 1:500-1000 |
| IF(ICC) | 1:50-200 |