IL-23 Polyclonal Antibody

Formalin-fixed and paraffin embedded human rhinopolypus labeled with Rabbit Anti IL-23 Polyclonal Antibody, Unconjugated (bs-1193R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

$Lane 1: Mouse Ear tissue lysates; Lane 2: Human A431 cell lysates; Lane 3: Human Jurkat cell lysates probed with IL-23 Polyclonal Antibody, Unconjugated (bs-1193R) at 1:1000 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.$

Lane 1: Mouse Ear tissue lysates; Lane 2: Human A431 cell lysates; Lane 3: Human Jurkat cell lysates probed with IL-23 Polyclonal Antibody, Unconjugated (bs-1193R) at 1:1000 dilution and 4\u00b0C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.

Applications

WB
ELISA
IHC-P
IHC-F
IF

Reactivity

Human
Rat

Predicted Reactivity

Mouse

Overview
Catalog #	bs-1193R
Product Name	IL-23 Polyclonal Antibody
Applications	WB ELISA IHC-P IHC-F IF
Reactivity	Human, Rat
Predicted Reactivity	Mouse
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	KLH conjugated synthetic peptide derived from human Il23a
Clonality	Polyclonal
Isotype	IgG
Concentration	1ug/ul
Purification	Purified by Protein A.
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage Condition	Shipped at 4_. Store at -20_ for one year. Avoid repeated freeze/thaw cycles.
Target
Gene ID	51561
Swiss Prot	Q9NPF7
Subcellular location	Secreted
Synonyms	P19; SGRF; IL-23; IL-23A; IL23P19; Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23-A; Interleukin-23 subunit p19; IL-23p19; IL23A; UNQ2498/PRO5798
Background	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Application Dilution
WB	1:500-2000
ELISA	1:5000-10000
IHC-P	1:200-400
IHC-F	1:100-500
IF