GABAA Receptor 2 Antibody

Applications

Reactivity

Mouse
Rat

Predicted Reactivity

Human
Dog
Bovine
Non-Human Primate

Overview
Catalog #	bs-70104r
Product Name	GABAA Receptor 2 Antibody
Applications	WB
Specificity	Specific for endogenous levels of the ~55 kDa _2-subunit of the GABAA receptor.
Reactivity	Mouse, Rat
Predicted Reactivity	Human, Dog, Bovine, Non-Human Primate
Specifications
Conjugation	Unconjugated
Host	Rabbit
Source	Fusion protein from the cytoplasmic loop of the 2 subunit of rat GABAA receptor.
Clonality	Polyclonal
Clone #	#REF!
Isotype	IgG
Concentration	Lot Dependent
Purification	Antigen Affinity purification
Storage Buffer	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 g per ml BSA and 50% glycerol.
Storage Condition	Storage at -20C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20C.
Target
Gene ID	25451
Swiss Prot	P63138
Synonyms	GABA antibody, GABA(A) receptor beta 2 antibody, GABA(A) receptor subunit beta-2 antibody, GABA-A receptor, beta-2 polypeptide antibody, GABRB2 antibody, Gamma aminobutyric acid (GABA) A receptor, beta 2 antibody, Gamma aminobutyric acid A receptor beta 2 antibody, Gamma-aminobutyric acid receptor subunit beta-2 antibody, Gamma-aminobutyric-acid receptor subunit beta-2 antibody, GBRB2_HUMAN antibody
Background	Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl_ channel associated with the GABA-A receptor (GABA-A-R) subtype. GABA-A-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABA-A-R is a multimeric subunit complex. To date six _s, four _s and four _s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for _- and _-subunits results in the expression of functional GABA-A-Rs sensitive to GABA. However, coexpression of a _-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different _- subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pltl et al., 2003).
Application Dilution
WB	1:300-5000